Reacción #66676

Ecuación de reacción

4-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole

K2CO3

→

2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 8 hrs
2. 2
   OtroSolvent was removed in vacuo
3. 3
   Otrothe residue was partitioned between methylene chloride and water
4. 4
   ExtracciónThe combined organic extract
5. 5
   Secadowas dried over Na2SO4
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated

Procedimiento

A mixture of 4-[4-Isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-phenyl]-thiazole (1.0 g, 2.27 mmol) and K2CO3 (1.6 g, 11.34 mmol) in anhydrous MeOH (10 ml) was refluxed for 8 hrs. Solvent was removed in vacuo and the residue was partitioned between methylene chloride and water. The combined organic extract was dried over Na2SO4, filtered, and concentrated to give 2-Isopropyl-4-methoxy-5-thiazol-4-yl-phenol.

Fuente