Reacción #66674

Ecuación de reacción

1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene

NaOH

HCl

→

2-Isopropyl-4-methoxy-5-trifluoromethyl-phenol

Rendimiento 81.0%

Disolventes

MeOH

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe cooled reaction mixture
2. 2
   Extracciónextracted into methylene chloride
3. 3
   SecadoThe combined extracts was dried with Na2SO4
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated

Procedimiento

A solution of 1-Isopropyl-5-methoxy-2-(toluene-4-sulfonyl)-4-trifluoromethyl-benzene (0.40 g, 1.03 mmol) and NaOH (0.5 g, 12.5 mmol) in MeOH (5 ml) and H2O (5 ml) was heated at 90° C. for 2 hrs. The cooled reaction mixture was acidified with 3N HCl and extracted into methylene chloride. The combined extracts was dried with Na2SO4, filtered and concentrated to give desired 2-Isopropyl-4-methoxy-5-trifluoromethyl-phenol (0.194 g, 81%) as an oil.

Fuente