Reacción #66672

Ecuación de reacción

2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene

ICl

NaHCO3

→

1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene

Rendimiento 91.8%

Disolventes

HOAc

HOAc

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe aqueous solution was extracted into EtOAc which
2. 2
   Lavadowas washed with water, brine
3. 3
   Secadodried over Na2SO4
4. 4
   Filtraciónfiltered
5. 5
   Concentraciónconcentrated in vacuo

Procedimiento

To a solution of 2-Isopropyl-4-methoxy-1-(toluene-4-sulfonyl)-benzene (10 g, 31.25 mmol) in HOAc (10 ml) was added a solution of ICl (9.6 g, 59.26 mmol) in HOAc (10 ml) and H2O (5 ml). The reaction mixture was stirred at room temperature for 16 hrs and basified by saturated NaHCO3 solution. The aqueous solution was extracted into EtOAc which was washed with water, brine, dried over Na2SO4, filtered and concentrated in vacuo to give 1-Iodo-4-isopropyl-2-methoxy-5-(toluene-4-sulfonyl)-benzene (12.35 g, 89%).

Fuente