Reacción #66556

Ecuación de reacción

Toluene

product

(2S)-4-[[5-chloro-2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]phenyl]methyl]-2-ethyl-1-piperazinecarboxylic Acid, 1,1-Dimethylethyl Ester

trifluoroacetic acid

→

sub-titled compound

[4-Chloro-2-[[(3S)-3-ethyl-1-piperazinyl]methyl]phenoxy]-acetic Acid, 1,1-dimethylethyl Ester Trifluoroacetate Salt

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroreaction
2. 2
   Concentraciónwas concentrated (bath temp <40° C.) in vacuo

Procedimiento

To a solution of the product from example 69 part e) (2 g) in dichloromethane (100 ml) was added trifluoroacetic acid (100 ml). The mixture was stirred at RT for 24 h. Toluene (100 ml) was added and reaction was concentrated (bath temp <40° C.) in vacuo to give the sub-titled compound as a yellow oil (3.10 g).

Fuente