Reacción #66534

Ecuación de reacción

Acetic acid

sulfonyl chloride

product

[4-chloro-2-(1-piperazinylmethyl)phenoxy]-acetic Acid, Ethyl Ester

NaOH

→

sub-title compound

[4-chloro-2-[4-(phenylsulfonyl)-1-piperazinylmethyl]phenoxy]-acetic Acid

Disolventes

triethylamine

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirred for 2 hours
2. 2
   Concentraciónthe reaction mixture was concentrated in vacuo
3. 3
   OtroThe residue was further purified by RPHPLC

Procedimiento

The product of example 11 part b (300 mg) was dissolved in THF (10 ml) and triethylamine (0.28 ml). The sulfonyl chloride (1.1 equivalents) was added and stirred for 3 h. 1M NaOH (3 ml) was added and stirred for 2 hours. Acetic acid (5 ml) was added and then the reaction mixture was concentrated in vacuo. The residue was further purified by RPHPLC to give the sub-title compound (0.19 g).

Fuente