Reacción #66528

Ecuación de reacción

tert-butyl 4-(2-chloro-4-nitrophenyl)piperazine-1-carboxylate

→

tert-butyl 4-(4-amino-2-chlorophenyl)piperazine-1-carboxylate

Rendimiento 98.4%

Disolventes

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThen the solution was concentrated under reduced pressure

Procedimiento

According to Scheme 5 Step 2: A solution of tert-butyl 4-(2-chloro-4-nitrophenyl)piperazine-1-carboxylate (2.50 mmol, 854 mg) in EtOH (450 mL) was passed through a Pt/C 5% column in an H-Cube equipment (mode: Full). Then the solution was concentrated under reduced pressure to yield tert-butyl 4-(4-amino-2-chlorophenyl)piperazine-1-carboxylate (2.46 mmol, 766 mg, 98%). The product was used without further purification.

Fuente