Reacción #66513

Ecuación de reacción

4-iodo-1H-pyrazole

1-(chloromethyl)-4-methoxybenzene

K2CO3

→

4-iodo-1-(4-methoxybenzyl)-1H-pyrazole

Rendimiento 88.2%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was cooled to room temperature
2. 2
   Filtraciónwas filtered
3. 3
   ConcentraciónThe filtrate was concentrated under reduced pressure
4. 4
   OtroThe crude product was purified by flash chromatography over silica gel

Procedimiento

According to Scheme 6 Step 1: A suspension of 4-iodo-1H-pyrazole (26.3 mmol, 5.11 g), 1-(chloromethyl)-4-methoxybenzene (29.0 mmol, 3.95 mL) and K2CO3 (39.5 mmol, 5.46 g) in acetonitrile (150 mL) was heated at 60° C. overnight. The reaction mixture was cooled to room temperature and was filtered. The filtrate was concentrated under reduced pressure. The crude product was purified by flash chromatography over silica gel using DCM as eluent to afford 4-iodo-1-(4-methoxybenzyl)-1H-pyrazole (23.2 mmol, 7.3 g, 88%) as a yellow solid.

Fuente