Reacción #66494

Ecuación de reacción

3-amino-1-propanol

N-ethyldiisopropylamine

2,4-dichloro-5-iodo-pyrimidine

→

3-(2-chloro-5-iodopyrimidine-4-ylamino)propan-1-ol

Rendimiento 95.0%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroprovided the target compound after column chromatography in 95% yield

Procedimiento

In analogy to GP 2 reaction of 3-amino-1-propanol (0.38 ml, 5 mmol) in the presence of N-ethyldiisopropylamine (1.74 ml, 10 mmol) in 150 ml acetonitrile with 2,4-dichloro-5-iodo-pyrimidine (1.51, 5.5 mmol) provided the target compound after column chromatography in 95% yield.

Fuente