Reacción #66458

Ecuación de reacción

8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one

triethylamine hydrochloride

POCl3

→

solid

Rendimiento 89.0%

4-Chloro-8-methoxy-2-(2-trifluoromethyl-phenyl)-quinazoline

Rendimiento 89.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroPurification by flash chromatography

Procedimiento

Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).

Fuente