Reacción #66420

Ecuación de reacción

(4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

phthalic anhydride

→

desired compound

Rendimiento 55.0%

[4-(1,3-dioxobenzo[c]azolidin-2-yl)phenyl]-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide

Rendimiento 55.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was cooled
2. 2
   Otropurified by RP-HPLC

Procedimiento

A 22 mg portion (0.070) of (4-aminophenyl)-N-[(5-chloro(2-thienyl))sulfonyl]carboxamide was combined with 15 mg (0.10 mmol) of phthalic anhydride in 140 μL of DMF. After 18 h of heating at 110° C., the mixture was cooled and purified by RP-HPLC, to give 20 mg (55%) of the desired compound. ES-MS (M+H)+=447 (Cl).

Fuente