Reacción #66361

Ecuación de reacción

2-[1,3]Dithietan-2-ylidene-1-(3-methoxy-phenyl)-2-pyridin-4-yl-ethanone

hydrazine

→

5-(3-methoxy-phenyl)-4-pyridin-4-yl-2H-pyrazole-3-thiol

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe suspension was then concentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with THF (10 mL)
3. 3
   FiltraciónThe solid was filtered
4. 4
   Lavadowashed with THF
5. 5
   Otrodried at 50° C. for 2 hours

Procedimiento

2-[1,3]Dithietan-2-ylidene-1-(3-methoxy-phenyl)-2-pyridin-4-yl-ethanone (1.18 g, 3.17 mmol) was suspended into a 1 M solution of hydrazine in THF and heated to 70° C. for two hours. The suspension was then concentrated under reduced pressure, taken up with a small volume of ethanol and diluted with THF (10 mL) and stirred for 5 minutes. The solid was filtered, washed with THF and dried at 50° C. for 2 hours. 1.26 g of 5-(3-methoxy-phenyl)-4-pyridin-4-yl-2H-pyrazole-3-thiol were obtained as an orange solid and used in the following step without further purification.

Fuente