Reacción #66344

Ecuación de reacción

1-(3-Bromo-phenyl)-2-pyridin-4-yl-ethanone

dibromomethane

carbon disulfide

K2CO3

→

1-(3-bromo-phenyl)-2-[1,3]dithietan-2-ylidene-2-pyridin-4-yl-ethanone

Rendimiento 74.0%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction
2. 2
   Otroevaporated to dryness
3. 3
   LavadoThe pooled organic extracts were washed with brine
4. 4
   Secadodried over sodium sulphate
5. 5
   Otroevaporated down
6. 6
   OtroThe crude material was purified by a quick elution with ethyl acetate through a pad of silica
7. 7
   Otroto give the clean product in 74% yield

Procedimiento

1-(3-Bromo-phenyl)-2-pyridin-4-yl-ethanone (150 mg, 0.54 mmol), dibromomethane (114 ul, 1.62 mmol) and carbon disulfide (77 ul, 1.62 mmol) were reacted at room temperature in dry DMSO in the presence of K2CO3 (225 mg, 1.62 mmol) for three hours. The reaction, evaporated to dryness, was worked up with water and ethyl acetate. The pooled organic extracts were washed with brine, dried over sodium sulphate and evaporated down. The crude material was purified by a quick elution with ethyl acetate through a pad of silica to give the clean product in 74% yield.

Fuente