Reacción #662703

Ecuación de reacción

metformin hydrochloride

paraldehyde

→

4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride

Rendimiento 176.6%

Disolventes

isobutanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroSynthesis
2. 2
   Temperaturawas heated
3. 3
   Temperaturaunder reflux for 6 hours
4. 4
   FiltraciónThe catalyst was subsequently filtered off
5. 5
   Otrosome of the solvent was removed by distillation
6. 6
   Otrothe white precipitate was separated off

Procedimiento

Synthesis according to the invention: A mixture of 100.1 g of metformin hydrochloride, 36.5 g of paraldehyde and 4 g of Dowex DR-2030 in 237.8 ml of isobutanol was heated under reflux for 6 hours. The catalyst was subsequently filtered off, and some of the solvent was removed by distillation. The remainder of the solution was cooled to 10-15° C., and the white precipitate was separated off, giving 93.5 g (80.7%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.

Fuente