Reacción #661720

ord-6831907c13654cd8a5ad088cba96c332

Ecuación de reacción

Cc1ccc2[nH]c3c(c2c1)CN(C)CC3
2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
C=Cc1ccc(=O)n(C)c1
1-methyl-5-vinylpyridin-2(1H)-one
[K+].[OH-]
KOH
→
Cc1ccc2c(c1)c1c(n2CCc2ccc(=O)n(C)c2)CCN(C)C1
title compound
Cc1ccc2c(c1)c1c(n2CCc2ccc(=O)n(C)c2)CCN(C)C1
5-(2-(1,2,3,4-tetrahydro-2,8-dimethylpyrido[4,3-b]indol-5-yl)ethyl)-1-methylpyridin-2(1H)-one

Reactantes

Cc1ccc2[nH]c3c(c2c1)CN(C)CC3
2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole
C=Cc1ccc(=O)n(C)c1
1-methyl-5-vinylpyridin-2(1H)-one
[K+].[OH-]
KOH

Reactivos

Ninguno

Disolventes

CN1CCCC1=O
NMP

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroranging between 25 deg C
  2. 2
    Otroto 100 deg C
  3. 3
    OtroThe product obtained
  4. 4
    Otrois isolated by preparative HPLC

Procedimiento

The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, 1-methyl-5-vinylpyridin-2(1H)-one and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09034880B2uspto-grants-2015_05