Reacción #66172

Ecuación de reacción

compound

Ethyl (5-bromopyridin-3-yl)acetate

dimethylformamide diethyl acetal

→

Ethyl 3-(dimethylamino)-2-(5-bromopyridin-3-yl)acrylate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Concentraciónthe mixture is concentrated under reduced pressure
3. 3
   Filtraciónthe solid is filtered off
4. 4
   Lavadofinally washed with diisopropyl ether
5. 5
   SecadoThe crude product is dried under reduced pressure for 16 h.

Procedimiento

5.1 g (20.9 mmol) of the compound from Example 10A are stirred in 7.2 ml (6.2 g, 41.8 mmol) of dimethylformamide diethyl acetal at a bath temperature of 100° C. for 16 h. After cooling, the mixture is concentrated under reduced pressure, the residue is stirred in diisopropyl ether, and the solid is filtered off and finally washed with diisopropyl ether. The crude product is dried under reduced pressure for 16 h.

Fuente