Reacción #6611

Ecuación de reacción

water

2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene

ethyl 4-hydroxybenzoate

potassium carbonate

→

title compound

Rendimiento 50.8%

4-Carbethoxyphenyl 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylmethyl ether

Rendimiento 50.8%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted several times with ether
2. 2
   Lavadothe organic phase was washed with water
3. 3
   Secadodried over Na2SO4
4. 4
   Concentraciónconcentrated
5. 5
   OtroRecrystallization from methanol

Procedimiento

10 g (36 mmol) of 2-bromomethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene, 6 g (36 mmol) of ethyl 4-hydroxybenzoate and 7.2 g (52 mmol) of anhydrous potassium carbonate in 60 ml of dimethylformamide were refluxed for 5.25 h. The mixture was then poured into water and extracted several times with ether, and the organic phase was washed with water, dried over Na2SO4 and concentrated. Recrystallization from methanol resulted in 6.7 g of the title compound of melting point 109°-11° C.

Fuente