Reacción #6602

Ecuación de reacción

aluminum chloride

phenol

2,5-dichloro-2,5-dimethylhexane

→

title compound

Rendimiento 32.1%

5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthol

Rendimiento 32.1%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ether
2. 2
   Lavadothe organic phase was washed
3. 3
   Secadodried over sodium sulfate
4. 4
   Otroevaporated under reduced pressure
5. 5
   OtroTwo recrystallizations of the residue from methanol

Procedimiento

27.5 g (0.2 mol) of anhydrous aluminum chloride were added by spatula to 250.0 g (2.65 mol) of phenol plus 414.5 g (2.27 mol) of 2,5-dichloro-2,5-dimethylhexane in 500 ml of petroleum ether at room temperature while stirring. After 48 hours, the reaction mixture was poured into ice-water and extracted with ether, and the organic phase was washed to neutrality with water, dried over sodium sulfate and evaporated under reduced pressure. Two recrystallizations of the residue from methanol yielded 148.7 g of the title compound of melting point 219°-220 C.

Fuente