Reacción #65949

Ecuación de reacción

(R)-8-fluoro-5-methoxy-3-aminochroman

3-pentanone

NaBH3CN

3-pentanone

acetic acid

→

NH3

(R)-8-fluoro-5-methoxy-3-(N-3-pentylamino)chroman

Rendimiento 176.4%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe solution was stirred at room temp. for 3 hours
2. 2
   ConcentraciónConcentration and extraction with 100 ml 2M NH3 and 2×250 ml EtOAc
3. 3
   Secadodrying of the combined organic phases (Na2SO4) and evaporation
4. 4
   Otrogave a crude product that
5. 5
   Otrowas purified by flash chromatography on silica with hexane

Procedimiento

To a stirred solution of (R)-8-fluoro-5-methoxy-3-aminochroman (3.13 g, 15.9 mmol) and 3-pentanone (2.2 ml, 20.8 mmol) in 100 ml dry MeOH, NaBH3CN (1.31 g, 20.8 mmol) was added during 10 min. The pH was adjusted to pH was adjusted to pH 6 with acetic acid and the solution was stirred at room temp. After 18 hours, 3-pentanone (0.5 ml, 4.7 mmol) was added and the solution was stirred at room temp. for 3 hours. Concentration and extraction with 100 ml 2M NH3 and 2×250 ml EtOAc, drying of the combined organic phases (Na2SO4) and evaporation gave a crude product that was purified by flash chromatography on silica with hexane:EtOAC:NH3, 60:40:0.5, to give 3.75 g of (R)-8-fluoro-5-methoxy-3-(N-3-pentylamino)chroman as an uncolored oil. [α]D22 -25° (c 1.14 in MeOH).

Fuente