Reacción #65903

Ecuación de reacción

HCl

HCl

sodium cyanide

anisaldehyde

triethylamine

→

p-methoxybenzaldehyde cyanohydrin

Disolventes

ethyl alcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ALIQUOTIn situ sampling of the reaction mixture
2. 2
   Otrothe reaction
3. 3
   Otroto quench
4. 4
   Otrothe reaction
5. 5
   FiltracióntHE solution is filtered
6. 6
   Otroused in the next step without further purification
7. 7
   OtroYield

Procedimiento

To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.

Fuente