Reacción #65843

Ecuación de reacción

3-benzyloxybromobenzene

1-ethoxycarbonyl-2-methylpyrrolidin-3-one

methyl iodide

→

(2RS,3SR)-3-(3-benzyloxyphenyl)-1-ethoxycarbonyl-3-methoxy-2-methylpyrrolidine

Rendimiento 65.0%

Condiciones de reacción

Procedimiento

Using an analogous procedure to that described in the portion of Example 1 which is concerned with the preparation of starting materials, 3-benzyloxybromobenzene was reacted with 1-ethoxycarbonyl-2-methylpyrrolidin-3-one (J. Med. Pharm. Chem., 1962, 5, 755) and the resultant product was reacted with methyl iodide to give (2RS,3SR)-3-(3-benzyloxyphenyl)-1-ethoxycarbonyl-3-methoxy-2-methylpyrrolidine in 65% yield as an oil.

Fuente