Reacción #657349

Ecuación de reacción

5-methoxyanthranilic acid

acetic anhydride

→

title compound

Rendimiento 77.0%

2-methyl-6-(methyloxy)-4H-3,1-benzoxazin-4-one

Rendimiento 77.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturabefore being cooled
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   ConcentraciónThe crude residue was then concentrated twice in the presence of toluene
4. 4
   Filtraciónbefore being filtered
5. 5
   Lavadowashed with ether

Procedimiento

A solution of 5-methoxyanthranilic acid (7.8 g, 46.5 mmol) was refluxed in acetic anhydride (60 mL) for 2 h15 before being cooled and concentrated under reduced pressure. The crude residue was then concentrated twice in the presence of toluene before being filtered and washed with ether to yield to the title compound (6.8 g, 77% yield) as a beige solid; LC/MS: m/z 192 [M+H]+, Rt 1.69 min.

Fuente