Reacción #657330

Ecuación de reacción

benzyl chloroformate

4-amino-piperidine-1-carboxylic acid tert-butyl ester

sodium bicarbonate

→

tan solid

Rendimiento 104.5%

4-Benzyloxycarbonylamino-piperidine-1-carboxylic acid tert-butyl ester

Rendimiento 104.5%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothen partitioned between ethyl acetate (200 mL) and water (100 mL)
2. 2
   OtroThe organic layer was separated
3. 3
   Lavadowashed with saturated brine solution (200 mL)
4. 4
   Secadodried (MgSO4)
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated

Procedimiento

To a solution of 4-amino-piperidine-1-carboxylic acid tert-butyl ester (11.98 g, 58.4 mmol, 1 equiv) in THF (80 mL) at 23° C. was added a saturated solution of sodium bicarbonate (200 mL) followed by benzyl chloroformate (9.19 mL, 64.2 mmol, 1.1 equiv). The reaction was stirred for 55 min then partitioned between ethyl acetate (200 mL) and water (100 mL). The organic layer was separated, washed with saturated brine solution (200 mL), dried (MgSO4), filtered and concentrated to give 20.4 g of tan solid. This material was used in the next step without further purification.

Fuente