Reacción #657275

Ecuación de reacción

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid

N-Hydroxysuccinimide

N,N′-Dicyclohexyl-carbodiimide

→

[2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid-(2,5-dioxo-pyrrolidine-1-yl)-ester

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe solution was filtered
2. 2
   Otrothe filtrate was evaporated in vacuo to dryness
3. 3
   workup.DISSOLUTIONThe residue was dissolved in 50 mL dichloromethane
4. 4
   workup.ADDITIONtreated with charcoal
5. 5
   FiltraciónAfter filtration
6. 6
   Otrothe solution was evaporated in vacuo to dryness
7. 7
   Otrothe product was recrystallised from ethyl acetate

Procedimiento

4.54 g (20 mMol) [2-(2,6-Dimethyl-piperidin-1-yl)acetylamino]-acetic acid (30) were added to 2.30 g (20 mMol) N-Hydroxysuccinimide and 4.12 g (20 mMol) N,N′-Dicyclohexyl-carbodiimide dissolved in 150 ml dichloromethane. The reaction mixture was stirred for 16 h at room temperature. The solution was filtered and the filtrate was evaporated in vacuo to dryness. The residue was dissolved in 50 mL dichloromethane and treated with charcoal. After filtration, the solution was evaporated in vacuo to dryness and the product was recrystallised from ethyl acetate.

Fuente