Reacción #657257

Ecuación de reacción

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

Rendimiento 44.0%

Disolventes

ethanol acetone

HCl

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   TemperaturaAfter cooling to room temperature
3. 3
   Filtraciónthe reaction mixture was filtered
4. 4
   Lavadowashed with dichloromethane
5. 5
   Extracciónextracted with dichloromethane
6. 6
   Secadodried over MgSO4
7. 7
   Otrothe solvent was evaporated under vacuum

Procedimiento

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

Fuente