Reacción #656787

Ecuación de reacción

dichloromethyl 2-(p-chlorophenoxy)-ethyl ether

triethyl phosphite

ethyl chloride

→

Tetraethyl [2-(p-chlorophenoxy)-ethoxymethylene]-bisphosphonate

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was cooled
2. 2
   Lavadowashed with aqueous sodium bicarbonate
3. 3
   Otrodried
4. 4
   Otroevaporated
5. 5
   OtroUnreacted triethyl phosphite was removed in vacuo
6. 6
   Otrothe crude product was used in the next step without further purification

Procedimiento

Anhydrous zinc chloride (10 g) was added at 150° C. to a mixture of dichloromethyl 2-(p-chlorophenoxy)-ethyl ether (5.1 g) and triethyl phosphite (6.9 ml). When the evolution of ethyl chloride ceased, the mixture was cooled, taken up in ether (250 ml), washed with aqueous sodium bicarbonate, dried and evaporated. Unreacted triethyl phosphite was removed in vacuo, and the crude product was used in the next step without further purification.

Fuente