Reacción #6563

Ecuación de reacción

5-acetamino-2-chloro-4-fluoro-thiophenol

sodium hydroxide

hydrochloric acid

→

5-amino-2-chloro-4-fluoro-thiophenol

Rendimiento 97.9%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   Temperaturaunder reflux for 4 hours
3. 3
   Otroto obtain a uniform solution
4. 4
   ExtracciónThe precipitated solid was extracted with 25 cc of ethyl acetate
5. 5
   Otrofollowed by removal of water and distillation under reduced pressure

Procedimiento

Into a 100 ml reaction flask, 4.8 g (0.022 mol) of 5-acetamino-2-chloro-4-fluoro-thiophenol, 2.55 g (0.064 mol) of sodium hydroxide and 25.5 cc of water were added and stirred under reflux for 4 hours to obtain a uniform solution. The solution was cooled to room temperature and neutralized with 10% hydrochloric acid. The precipitated solid was extracted with 25 cc of ethyl acetate, followed by removal of water and distillation under reduced pressure to obtain 3.8 g of 5-amino-2-chloro-4-fluoro-thiophenol as slightly yellow crystals.

Fuente