Reacción #655503

Ecuación de reacción

carbon tetrachloride

(s)-2-chloro-3-methylbutanic acid chloride

4-(4'-hydroxyphenyl)benzoic acid

pyridine

carbon tetrachloride

→

(s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturawith refluxing for 3 hours
3. 3
   OtroAfter removing the solvent
4. 4
   workup.ADDITIONa small amount of water was added
5. 5
   Lavado(s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid (H) after washing the residue with methanol
6. 6
   Otro5 ml of thionylchloride was reacted with the compound (H)

Procedimiento

Three point five grams of 4-(4'-hydroxyphenyl)benzoic acid were dispersed in a mixed solvent of 30 ml of carbon tetrachloride and 5 ml of pyridine and then heated. 2.5 ml of (s)-2-chloro-3-methylbutanic acid chloride was dropped into the mixed solution with refluxing for 3 hours. After removing the solvent, a small amount of water was added to decompose unreacted nonanic acid chloride. (s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid (H) after washing the residue with methanol. 5 ml of thionylchloride was reacted with the compound (H) dispersed in 20 ml of carbon tetrachloride to obtain 6.5 g of (s)-4-(4'-(1-chloro-2-methylpropylcarbonyloxy)phenyl)benzoic acid chloride (I).

Fuente