Reacción #65471

Ecuación de reacción

1-(2-cyclopropylphenyl)piperazine

3-bromo-N-methyl-N-(triphenylmethyl)propanamine

potassium carbonate

→

3-[4-(2-cyclopropylphenyl)piperazin-1-yl]-N-methyl-N-(tri-phenylmethyl)propanamine

Rendimiento 18.2%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroequipped with a reflux condenser
2. 2
   OtroThe solvent is evaporated under reduced pressure
3. 3
   Otrothe organic phase is separated
4. 4
   Lavadowashed with water
5. 5
   Secadodried over sodium sulphate
6. 6
   Otrothe solvent is evaporated under reduced pressure

Procedimiento

9.0 g (0. 0444 mol) of 1-(2-cyclopropylphenyl)piperazine, 200 ml of dimethylformamide, 17.5 g (0.0444 mol) of 3-bromo-N-methyl-N-(triphenylmethyl)propanamine and 9 g of potassium carbonate are introduced into a 500 ml round-bottomed flask equipped with a reflux condenser and placed under nitrogen, and the mixture is heated three times for 6 h at 96° C. The solvent is evaporated under reduced pressure, the residue is taken up with water and dichloromethane, the organic phase is separated, washed with water, dried over sodium sulphate and the solvent is evaporated under reduced pressure. There are obtained 4.17 g of 3-[4-(2-cyclopropylphenyl)piperazin-1-yl]-N-methyl-N-(tri-phenylmethyl)propanamine in the form of an oil which is dissolved in 200 ml of methanol, a stream of gaseous hydrochloric acid is passed therein for 10 min, the mixture is concentrated, allowed to stand for 2 days and the precipitate is separated by filtration. 2.94 g of compound are obtained.

Fuente