Reacción #65428

Ecuación de reacción

3-methyl-4-phenylthiobenzoic acid

sulfuric acid

methanol

→

methyl 3-methyl-4-phenylthiobenzoate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 4 hours
2. 2
   OtroAfter reaction
3. 3
   Concentraciónthe reaction mixture was concentrated in vacuo, and 1.5 liters of ethyl acetate
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   Lavadothe mixture was washed with saturated brine (400 ml×3)
6. 6
   Secadodried with anhydrous sodium sulfate
7. 7
   Concentraciónconcentrated in vacuo

Procedimiento

A mixture was 85 g of 3-methyl-4-phenylthiobenzoic acid, 20 ml of concentrated sulfuric acid, and 1.2 liters of methanol was refluxed for 4 hours while stirring. After reaction, the reaction mixture was concentrated in vacuo, and 1.5 liters of ethyl acetate was added to the residue, and the mixture was washed with saturated brine (400 ml×3), and dried with anhydrous sodium sulfate, concentrated in vacuo, and methyl 3-methyl-4-phenylthiobenzoate was obtained (80.33 g).

Fuente