Reacción #653606

Ecuación de reacción

hydrochloric acid

1-Tetradecylamine

cis-4-cyclohexene-1,2-dicarboxylic anhydride

sodium borohydride

→

compound

Rendimiento 93.1%

6-(Hydroxymethyl)-N-tetradecyl-3-cyclohexene-1-carboxamide

Rendimiento 93.1%

Disolventes

2-propanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat room temperature
2. 2
   workup.STIRRINGAfter being stirred for 67.5 hours at room temperature
3. 3
   FiltraciónThe resulting solid was collected by filtration under a vacuum
4. 4
   Lavadowashed with water
5. 5
   Otrodried

Procedimiento

1-Tetradecylamine (3.51 g) was added to cis-4-cyclohexene-1,2-dicarboxylic anhydride (2.50 g) and stirred for 5 hours at 140° C. The reaction mixture was suspended into a mixed solution of 2-propanol (125 ml) and water (21 ml) and then sodium borohydride (3.11 g) was added thereto at room temperature. After being stirred for 67.5 hours at room temperature, the reaction mixture was acidified with dilute hydrochloric acid. The resulting solid was collected by filtration under a vacuum, washed with water, and dried, thereby yielding the entitled compound (5.38 g) as white solid.

Fuente