Reacción #65277

Ecuación de reacción

sodium hydroxide

potassium carbonate

2-n-butyl-[(4cyanophenyl)methyl]imidazole-5-aldehyde

2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde

methyl 3-(2-thienyl)propanoate

iv

(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid

→

title compound

(E)-3-[2-n-Butyl-1-{(4-cyanophenyl)methyl}-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic Acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroprepared by the method of Example 42 describing

Procedimiento

The title compound was prepared using 2-n-butyl-[(4cyanophenyl)methyl]imidazole-5-aldehyde (prepared by the method of Example 42 describing the preparation of 2-n-butyl-1-[(4-carboethoxy-2-chlorophenyl)methyl]imidazole-5-aldehyde) and methyl 3-(2-thienyl)propanoate by the procedure of Example 1 (iv, Method B), except, instead of basic hydrolysis of the ester with sodium hydroxide, potassium carbonate hydrolysis was employed; mp 190°-192° C.

Fuente