Reacción #651853

Ecuación de reacción

N-methylpyrrolidone

2-(trans-4-propylcyclohexyl)ethenyl bromide

copper cyanide

→

oily product

3-(trans-4-propylcyclohexyl)acrylonitrile

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturaunder reflux
3. 3
   Temperaturaby heating for 7 hours
4. 4
   Extracciónextracted with toluene
5. 5
   OtroThe organic layer thus obtained
6. 6
   Lavadowas washed with water
7. 7
   Otrodried
8. 8
   Concentraciónconcentrated under a reduced pressure
9. 9
   Otroto obtain a brown oily product
10. 10
    OtroThis product was isolated
11. 11
    Otropurified

Procedimiento

To 30 ml of N-methylpyrrolidone was dissolved 3 g of 2-(trans-4-propylcyclohexyl)ethenyl bromide, 2 g of copper cyanide was added thereto, and then stirred under reflux by heating for 7 hours. A solution of ferric chloride in 6N hydrochloric acid was added to the reaction liquid, and extracted with toluene. The organic layer thus obtained was washed with water, dried, and then concentrated under a reduced pressure to obtain a brown oily product. This product was isolated and purified by using silica gel column chromatography to obtain 1.5 g of an oily product. As a result of various instrumental analysises, the product was confirmed to be the subject compound.

Fuente