Reacción #65016

Ecuación de reacción

NaOH

p-anisaldehyde

acetophenone

→

4'-methoxychalcone

Rendimiento 56.0%

Disolventes

EtOH

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextract with ether
2. 2
   Lavadowash with water and brine
3. 3
   Secadodry over Na2SO4
4. 4
   Concentraciónconcentrate to a solid
5. 5
   OtroRecrystallize the solid from ether/hexanes

Procedimiento

Step A Add 10% aqueous NaOH (38 mL) to a solution of p-anisaldehyde (25 mL, 0.206 mol) and acetophenone (23.97 mL, 0.206 mol) in EtOH (500 mL). Stir the mixture at room temperature over night. Dilute the mixture with water and extract with ether. Combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to a solid. Recrystallize the solid from ether/hexanes to provide 27.51 g (56%) of 4'-methoxychalcone, mp 72°-74° C.

Fuente