Reacción #64935

Ecuación de reacción

1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine

sodium hydroxide

→

8-Benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

Disolventes

sulphuric acid

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe sodium sulphate which has precipitated
2. 2
   Filtraciónis filtered off with suction
3. 3
   Extracciónthe filtrate is extracted with chloroform
4. 4
   SecadoThe extract is dried over potassium carbonate
5. 5
   Concentraciónconcentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

Procedimiento

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

Fuente