Reacción #649055

Ecuación de reacción

3-(methylthio)propan-1-ol

Hunig's base

methanesulfonyl chloride

→

title compound

3-(Methylthio)propyl methanesulfonate

Disolventes

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting reaction mixture
2. 2
   Temperaturawarmed slowly to RT
3. 3
   OtroThe reaction was quenched with sat. aq. NH4Cl
4. 4
   Extracciónextracted with ether
5. 5
   LavadoThe combined organic extracts were washed with water and brine
6. 6
   Secadodried over MgSO4
7. 7
   Filtraciónfiltered
8. 8
   ConcentraciónConcentrated of the filtrate in vacuo

Procedimiento

To a solution of 3-(methylthio)propan-1-ol in dichloromethane (0.2 M) was added sequentially at −78° C. Hunig's base (1.3 eq.) and methanesulfonyl chloride (1.3 eq.). The resulting reaction mixture was stirred at −78° C. for 1 h and then warmed slowly to RT. The reaction was quenched with sat. aq. NH4Cl and then extracted with ether. The combined organic extracts were washed with water and brine, dried over MgSO4, and filtered. Concentrated of the filtrate in vacuo afforded the title compound as a yellow oil.

Fuente