Reacción #64903

Ecuación de reacción

Phosphorous oxychloride

sodium hydroxide

5-aminoacenaphthene

sodium nitromalondialdehyde monohydrate

aniline hydrochloride

→

8-Nitro-10-azaacephenanthrene

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGThis mixture was stirred for 10 min
2. 2
   Temperaturaheated
3. 3
   Temperaturaat reflux for 2 h
4. 4
   Temperaturaheating
5. 5
   workup.WAITwas continued for 3 h
6. 6
   TemperaturaThe resulting mixture was cooled to room temperature
7. 7
   Extracciónextracted with dichloromethane
8. 8
   SecadoThe extracts were dried over sodium sulfate and condensed to dryness
9. 9
   OtroThe condensed product was purified
10. 10
    Otroto obtain a fluffy, bright yellow solid, 3.20 g (43%)

Procedimiento

A mixture of 5-aminoacenaphthene (Grabe, C. Liebigs Ann. der Chemie 1903, 327, 77) (5.0 g, 29.5 mmol) and sodium nitromalondialdehyde monohydrate (Fanta, P. E. Org. Syntheses Coll. vol. 4 1963, 844) (5.51 g, 35 mmol) in acetic acid (140 mL) was stirred for 1 h at room temperature and aniline hydrochloride (5.21 g, 40.2 mmol) was added. This mixture was stirred for 10 min and heated at reflux for 2 h. Phosphorous oxychloride (3 mL, 32.2 mmol) was added and heating was continued for 3 h. The resulting mixture was cooled to room temperature and poured into ice/water (200 mL). The aqueous mixture was neutralized with 2M sodium hydroxide solution and extracted with dichloromethane. The extracts were dried over sodium sulfate and condensed to dryness. The condensed product was purified using flash chromatography (20% hexane/dichloromethane, silica gel) to obtain a fluffy, bright yellow solid, 3.20 g (43%): MS m/e 251 (M+H +); 1H NMR (CD2C12, 300 MHz) δ 3.48-3.55 (m, 4H), 7.56 (s, 1H), 7.68 (d, J=7.0 Hz, 1H), 7.77 (t, J=7.8 Hz, 1H), 8.79 (d, J=8.1 Hz, 1H), 8.94 (d, J=2.5 Hz, 1H), 9.65 (d, J=2.5 Hz, 1H).

Fuente