Reacción #648684

Ecuación de reacción

4-chloro-2-fluorobromobenzene

4-chloro-2-fluorobenzaldehyde

compound

(4-Chlorophenyl)(4-methoxyphenyl)methanol

→

title compound

Bis(4-chloro-2-fluorophenyl)methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was prepared
2. 2
   OtroA difference was that a preliminary separation by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate gradient)
3. 3
   Otrowas carried out before the purification of the crude product by preparative HPLC

Procedimiento

The title compound was prepared starting from 5.00 g (23.87 mmol) of 4-chloro-2-fluorobromobenzene and 4.54 g (28.65 mmol) of 4-chloro-2-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. A difference was that a preliminary separation by column chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate gradient) was carried out before the purification of the crude product by preparative HPLC. 1.79 g (26% of theory) of the title compound were obtained.

Fuente