Reacción #64763

Ecuación de reacción

diethyl 1,1-cyclopentane dicarboxylate

KOH

→

product

Rendimiento 0.1%

1-(Ethoxycarbonyl)cyclopentanecarboxylic acid

Rendimiento 0.1%

Disolventes

EtOH

EtOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated under vacuum
2. 2
   Otropartitioned between H2O and EtOAc
3. 3
   Extracciónextracted with EtOAc
4. 4
   LavadoThe EtOAc extracts were washed (brine)
5. 5
   Secadodried (Na2SO4)
6. 6
   Filtraciónfiltered
7. 7
   Concentraciónconcentrated under vacuum

Procedimiento

To a solution of diethyl 1,1-cyclopentane dicarboxylate (2.5 g, 11.68 mol) in EtOH (10 ml) was added dropwise a solution of KOH (654 mg, 11.68 mmol) in EtOH (10 ml) over 1/2 hour. The resulting mixture was stirred at room temperature for 96 hr, concentrated under vacuum, and partitioned between H2O and EtOAc. The aqueous layer was acidified with concentrated HCl and extracted with EtOAc. The EtOAc extracts were washed (brine), dried (Na2SO4), filtered, and concentrated under vacuum to give the product (1.73 g) as a clear oil.

Fuente