Reacción #64717

Ecuación de reacción

hydrogencarbonate

methanol

Compound 2

2-[Bis(4-acetoxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

→

desired product

Rendimiento 56.0%

2-[Bis(4-hydroxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

Rendimiento 56.0%

Disolventes

sodium

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe suspension was heated
2. 2
   Temperaturaunder reflux for 30 minutes
3. 3
   ConcentraciónThe resulting mixture was concentrated under reduced pressure, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   ExtracciónThe resulting mixture was extracted with ethyl acetate
6. 6
   Secadothe extract was dried over anhydrous magnesium sulfate
7. 7
   ConcentraciónAfter concentration under reduced pressure
8. 8
   Otrothe residue was recrystallized

Procedimiento

In a mixture of 50 ml of saturated aqueous sodium. hydrogencarbonate solution and 50 ml of methanol was suspended 2.6 g of Compound 2 prepared in Example 1, and the suspension was heated under reflux for 30 minutes. The resulting mixture was concentrated under reduced pressure, and water was added to the residue. The resulting mixture was extracted with ethyl acetate, and the extract was dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was recrystallized to afford 1.23 g of the desired product.

Fuente