Reacción #64682

Ecuación de reacción

Tetra(n-butyl)ammonium hydroxide

thymine

→

tetra (n-butyl) ammonium

thymine

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrothe dimethylformamide was removed in vacuo
2. 2
   workup.ADDITIONAdditional dimethylformamide (20 ml.) was added to the white residue
3. 3
   Otroremoved in vacuo
4. 4
   Otrothe residue was dried under a vacuum (0.1 mm) at 50° C. overnight

Procedimiento

1.5M Tetra(n-butyl)ammonium hydroxide (4.22 ml., 6.335 mmole) was added to a suspension of thymine (0.913 g., 7.24 mmole) in dimethylformamide (15 ml.). The mixture was stirred for 10 minutes, and the dimethylformamide was removed in vacuo. Additional dimethylformamide (20 ml.) was added to the white residue, and removed in vacuo. This process was repeated four times and the residue was dried under a vacuum (0.1 mm) at 50° C. overnight affording the tetra (n-butyl) ammonium salt of thymine.

Fuente