Reacción #646715

Ecuación de reacción

5-chloro-N-((1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

1-iodo-2-fluoro-4-(2-oxopyridin-1(2H)-yl)benzene

8-hydroxyquinoline

K2CO3

→

title compound

5-Chloro-N-((1-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas degassed with Ar
2. 2
   OtroIt was then purified by HPLC

Procedimiento

A mixture of 5-chloro-N-((1H-imidazol-4-yl)methyl)thiophene-2-carboxamide 3-1 prepared above (0.940 g, 2.64 mmol), 1-iodo-2-fluoro-4-(2-oxopyridin-1(2H)-yl)benzene 3-2 prepared above (0.820 g, 2.60 mmol), 8-hydroxyquinoline (0.066 g, 0.45 mmol) and K2CO3 (0.630 g, 4.56 mmol) in DMSO (8 mL) was degassed with Ar before being charged with CuI (0.090 g, 0.47 mmol). The mixture in a sealed tube was heated at 130° C. overnight. It was then purified by HPLC to give the title compound (0.480 g). MS 429.0 and 431.0 (M+H, Cl pattern).

Fuente