Reacción #64647

ord-8b7c9dcf4ce040aabd4e88121e025163

Ecuación de reacción

O=C1C(Cc2cnccn2)c2ccccc2N1c1ccccc1
2,3-dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)1H-indole
N#CCCCCBr
5-bromovaleronitrile
→
N#CCCCCC1(Cc2cnccn2)C(=O)N(c2ccccc2)c2ccccc21
desired product
Rendimiento 76.0%
N#CCCCCC1(Cc2cnccn2)C(=O)N(c2ccccc2)c2ccccc21
2,3-Dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)-1H-indole-3-pentanenitrile
Rendimiento 76.0%

Reactantes

O=C1C(Cc2cnccn2)c2ccccc2N1c1ccccc1
2,3-dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)1H-indole
N#CCCCCBr
5-bromovaleronitrile

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

By substituting 2,3-dihydro-2-oxo-1-phenyl-3-(2-pyrazinylmethyl)1H-indole and 5-bromovaleronitrile in Example 1, the desired product was obtained in 76% yield as an oil.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05414004uspto-grants-1995_05