Reacción #644694

Ecuación de reacción

dimethylamine

1,4-dioxa-spiro[4.5]decane-8-carbaldehyde

1,4-Dioxa-spiro[4.5]decane-8-carbaldehyde

potassium cyanide

hydrochloric acid

→

Dimethylamino-(1,4-dioxa-spiro[4.5]dec-8-yl)-acetonitrile

Disolventes

methanol

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with diethyl ether (4×100 ml)
2. 2
   SecadoThe organic phase was dried over sodium sulfate
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   Otrothe product was obtained in the form of a white solid

Procedimiento

40% aqueous dimethylamine solution (85 ml, 0.67 mol), 1,4-dioxa-spiro[4.5]decane-8-carbaldehyde 2 (240 g, 0.141 mol) and potassium cyanide (22.05 g, 0.338 mol) were added, while cooling with ice, to a mixture of 4N hydrochloric acid (37 ml) and methanol (22 ml). The mixture was stirred for 4 d at room temperature and then, after addition of water (80 ml), extracted with diethyl ether (4×100 ml). The organic phase was dried over sodium sulfate and concentrated in vacuo, and the product was obtained in the form of a white solid.

Fuente