Reacción #644560

Ecuación de reacción

2-fluoropyridine-3-carbonyl chloride

NaHCO3

4-tert butylaniline

→

desired compound

N-[4-(tert-butyl)phenyl]2-fluoropyridine-3-carboxamide

Disolventes

CH2Cl2

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter the addition
2. 2
   OtroSolid inorganic salts were removed via filtration
3. 3
   ConcentraciónThe filtrate was concentrated

Procedimiento

To a suspension of 2-fluoropyridine-3-carbonyl chloride (3.2 g, 20 mmol, Step D) and NaHCO3 (4 g, 48 mmol) in CH2Cl2 added in dropwise a solution of 4-tert butylaniline (3.0 g, 20 mmol). After the addition, the suspension was stirred at RT for 5 h. Solid inorganic salts were removed via filtration. The filtrate was concentrated to afford a brown solid as desired compound. MS: 273 (M+H). Calc'd. for C16H17FN2O−272.33.

Fuente