Reacción #644428

ord-41d24a823e5e47daa7c6dd3ab7c528bd

Ecuación de reacción

Cl.Oc1ccc(CCl)c2cccnc12
5-chloromethyl-8-hydroxyquinolinoline
Cl.Oc1ccc(CCl)c2cccnc12
5-chloromethyl-8-hydroxyquinoline hydrochloride
C#CCN1CCNCC1
N-propargyl piperazine
→
C#CCN1CCN(Cc2ccc(O)c3ncccc23)CC1
title compound
C#CCN1CCN(Cc2ccc(O)c3ncccc23)CC1
5-(4-propargylpiperazin-1-ylmethyl)-8-hydroxy-quinoline

Reactantes

Cl.Oc1ccc(CCl)c2cccnc12
5-chloromethyl-8-hydroxyquinolinoline
Cl.Oc1ccc(CCl)c2cccnc12
5-chloromethyl-8-hydroxyquinoline hydrochloride
C#CCN1CCNCC1
N-propargyl piperazine

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared by reaction of 5-chloromethyl-8-hydroxyquinolinoline (A2) with N-propargyl piperazine as follows:

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08058442B2uspto-grants-2011_11