Reacción #64400

Ecuación de reacción

magnesium

tetrahydrofuran

iodine

4-bromoanisole

→

solution A

methoxyphenylmagnesiumbromide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added to the reaction mixture
2. 2
   workup.ADDITIONAt the end of the addition
3. 3
   Otrodecanted

Procedimiento

A suspension of magnesium turnings (268 g; 11.02 moles--Janssen) in tetrahydrofuran (2695 g) was heated at 65° C. under stirring and under nitrogen. Then, iodine (2.7 g) and, after 30 minutes, 4-bromoanisole (2000 g; 10.69 moles), in 1 hour, were added to the reaction mixture. At the end of the addition, the reaction mixture was kept at 75° C. for 1 hour and, then, decanted obtaining a solution of methoxyphenylmagnesiumbromide (solution A).

Fuente