Reacción #643917

Ecuación de reacción

4b

3-[1-(2-Bromo-phenyl)-1H-pyrrol-2-yl]-propenal

aminoguanidine bicarbonate

acetic acid

→

final product 5b

Rendimiento 31.0%

[1-(2-Bromophenyl)-1H-pyrrol-2-yl-allylideneamino]guanidinium acetate

Rendimiento 31.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated
2. 2
   workup.DISSOLUTIONthe oily residue was dissolved in acetonitrile
3. 3
   workup.ADDITIONa few drops of diethyl ether was added
4. 4
   OtroAfter three days in refrigerator a precipitate was formed
5. 5
   Filtraciónthat was filtered
6. 6
   Lavadowashed with diethyl ether
7. 7
   Otrodried

Procedimiento

0.9 g (3.26 mmol) 4b and 1.2 eqv. of aminoguanidine bicarbonate was mixed in 10 ml of ethanol and 2 ml of acetic acid and refluxed for 30 min. The solvent was evaporated and the oily residue was dissolved in acetonitrile and a few drops of diethyl ether was added. After three days in refrigerator a precipitate was formed that was filtered, washed with diethyl ether and dried. 340 mg (31%) of the final product 5b was obtained as white crystals (m.p. 166-168° C.).

Fuente