Reacción #64308

Ecuación de reacción

4-bromobenzaldehyde

methyl orthoformate

methanol

→

1-bromo-4-(dimethoxymethyl)benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturaunder reflux for 5 hours
3. 3
   OtroThe solvent was removed under vacuum and distillation of the remaining residue

Procedimiento

A mixture of 4-bromobenzaldehyde (21.9 g, 120 mmol), methyl orthoformate (50 mL, 457 mmol), and para-toluenesulfonic acid (0.05 g, 0.29 mmol) in 100 mL of methanol was heated under reflux for 5 hours. The solvent was removed under vacuum and distillation of the remaining residue gave 1-bromo-4-(dimethoxymethyl)benzene (2.24 g, 9.7 mmol) as a clear colorless oil.

Fuente