Reacción #64296

Ecuación de reacción

ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate

methanethiol

methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate

→

desired product

Rendimiento 69.3%

Ethyl 2-butyl-1-[[2'-(methoxycarbonyl)-(1,1'-biphenyl)-4-yl]-methyl]-4-(methylthio)-1H-imidazole-5-carboxylate

Rendimiento 69.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroprepared
2. 2
   Otroas indicated in Stages C and D of Preparation 1

Procedimiento

The operation is carried out as in Example 5, starting with 0.6 g of ethyl 2-butyl-4-(methylthio)-1H-imidazole-5-carboxylate (prepared as indicated in Stages C and D of Preparation 1, replacing the ethanethiol with methanethiol), using 907 mg of methyl 4'-(bromomethyl)-(1,1'-biphenyl)-2 -carboxylate. After chromatography on silica (eluant: methylene chloride--ethyl acetate (97-3)), 0.8 g of the desired product is obtained.

Fuente