Reacción #64216

ord-ff946c18220b4bed99f4df292ed2a703

Ecuación de reacción

CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O
1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione
[H-].[Na+]
sodium hydride
CCCCCCCCCBr
1-bromo-nonane
→
CCCCCCCCCN1C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)C1(C)C
desired product
CCCCCCCCCN1C(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C(=O)C1(C)C
5,5-dimethyl-3-(4-nitro-3-trifluoromethyl-phenyl)-1-nonyl-2,4-imidazolidinedione

Reactantes

CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O
1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione
—
suspension
[H-].[Na+]
sodium hydride
CCCCCCCCCBr
1-bromo-nonane

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Using the procedure of Example 1, 1 g of 1-(3-trifluoromethyl-4-nitro-phenyl)-4,4-dimethyl imidazolidine-2,5-dione was reacted with a 50% suspension of 170 mg of sodium hydride in oil and 0.7 ml of 1-bromo-nonane to obtain after chromatography on silica 1.08 g of the desired product melting at 63° C.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05411981uspto-grants-1995_05